Self-polarization and directional motility of cytoplasm
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منابع مشابه
Self-polarization and directional motility of cytoplasm
BACKGROUND Directional cell motility implies the presence of a steering mechanism and a functional asymmetry between the front and rear of the cell. How this functional asymmetry arises and is maintained during cell locomotion is, however, unclear. Lamellar fragments of fish epidermal keratocytes, which lack nuclei, microtubules and most organelles, present a simplified, perhaps minimal, system...
متن کاملModel for self-polarization and motility of keratocyte fragments.
Computational modelling of cell motility on substrates is a formidable challenge; regulatory pathways are intertwined and forces that influence cell motion are not fully quantified. Additional challenges arise from the need to describe a moving deformable cell boundary. Here, we present a simple mathematical model coupling cell shape dynamics, treated by the phase-field approach, to a vector fi...
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15 صفحه اولDirectional Sensing Orients Cell Migration and Polarization
Cell migration is a complex process that requires the coordinated regulation of the cytoskeleton and cell adhesion. Actin polymerization at the cell cortex generates filaments that produce pseudopods and other membrane extensions that provide forward drive (34). In unstimulated Dictyostelium cells, pseudopods are formed at random positions independently of receptors and G proteins (FIGURE 1). T...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1999
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(99)80042-6